2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113033
    Pentosidine 124505-87-9 98%
    Pentosidine is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease.
    Pentosidine
  • HY-113049
    Phosphoenolpyruvic acid 138-08-9 98%
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid
  • HY-113077
    9-Hydroxy-10(E),12(E)-octadecadienoic acid 115185-06-3 98%
    9-Hydroxy-10(E),12(E)-octadecadienoic acid ((10E,12E)-9-Hydroxyoctadeca-10,12-dienoic acid) is an ester product.
    9-Hydroxy-10(E),12(E)-octadecadienoic acid
  • HY-113125
    Dolichol-20 2067-66-5 98%
    Dolichol-20 is an ester product.
    Dolichol-20
  • HY-113149
    Argininosuccinic acid 2387-71-5 98%
    Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc.
    Argininosuccinic acid
  • HY-113401
    Adenosine 2',3'-cyclic phosphate 634-01-5 98%
    Adenosine 2',3'-cyclic phosphate is a 2',3'-cyclic purine nucleotide. Adenosine 2',3'-cyclic phosphate can be degrade to 2'-AMP and 3'-AMP.
    Adenosine 2',3'-cyclic phosphate
  • HY-113407
    D-Fructose-6-phosphate 643-13-0 98%
    D-Fructose 6-phosphate is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose-6-phosphate can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose-6-phosphate is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate can be used to study Lewy body dementia.
    D-Fructose-6-phosphate
  • HY-113510
    9(S)-HOTrE 89886-42-0 98%
    9(S)-HOTrE is an ester product.
    9(S)-HOTrE
  • HY-113545
    9(R)-HODE 10075-11-3 98%
    9(R)-HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL.
    9(R)-HODE
  • HY-113553
    4-Aminophenylphosphorylcholine 102185-28-4
    4-Aminophenylphosphorylcholine ((p-Aminophenyl)phosphocholine) is a probe that can be conjugated to agarose gels to generate adsorbents for affinity precipitation experiments.
    4-Aminophenylphosphorylcholine
  • HY-113567
    GSK2324 1020567-30-9 98%
    GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively.
    GSK2324
  • HY-113655
    AD-5075 103788-05-2 98%
    AD-5075 is an orally active insulin sensitizer. AD-5075 mediates its antidiabetic activity by binding to PPARγ and thereby generating an active conformation of the receptor.
    AD-5075
  • HY-113775
    Octadecanoyl-L-threo-sphingosine 95037-06-2 98%
    Octadecanoyl-L-threo-sphingosine is an ester product.
    Octadecanoyl-L-threo-sphingosine
  • HY-113820
    AZD4619 1067247-60-2 98%
    AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug.
    AZD4619
  • HY-113836
    3-Hydroxyhexanoic acid 10191-24-9 98%
    3-Hydroxyhexanoic acid is an ester product.
    3-Hydroxyhexanoic acid
  • HY-113864
    Diisobutyl carbinol 108-82-7 98%
    Diisobutyl carbinol (DIBC) is an orally active organic solvent widely used as industrial intermediates and fragrance ingredient. Diisobutyl carbinol and Diisobutyl ketone are well interconverted metabolically in rats.
    Diisobutyl carbinol
  • HY-113884
    (R)-Coriolic acid 10219-69-9 98%
    13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.1 13(R)-HODE is a weak (IC50=2.7 μM) inhibitor of U-46619-induced platelet aggregation.
    (R)-Coriolic acid
  • HY-113925
    1,2-Dilauroyl-sn-glycero-3-phosphate sodium 108321-06-8 98%
    1,2-Dilauroyl-sn-glycero-3-phosphate (1,2-DLPA) sodium is a phospholipid containing the medium-chain (12:0) lauric acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other types of artificial membranes.
    1,2-Dilauroyl-sn-glycero-3-phosphate sodium
  • HY-114333
    Octyl-α-ketoglutarate 876150-14-0 98%
    Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.
    Octyl-α-ketoglutarate
  • HY-114509
    Anilazine 101-05-3 98%
    Anilazine is a fungicide and inhibit the growth of Rhizobium sp. and E. coli. Anilazine inhibits glucose oxidation and succinate oxidation and also inhibits in vitro succinic dehydrogenase activity.
    Anilazine
Cat. No. Product Name / Synonyms Application Reactivity